Photoluminescent carbon nanotags from harmful cyanobacteria for drug delivery and imaging in cancer cells

Title
Photoluminescent carbon nanotags from harmful cyanobacteria for drug delivery and imaging in cancer cells
Authors
허윤석
Issue Date
2014-04
Publisher
SCIENTIFIC REPORTS
Series/Report no.
SCIENTIFIC REPORTS ; Vol4 Article4665 Startpage 1 Endpage 7
Abstract
Using a simple method of mass production of green carbon nanotags (G-tags) from harmful cyanobacteria, we developed an advanced and efficient imaging platform for the purpose of anticancer therapy. Approximately 100 grams of G-tags per 100 kilograms of harmful cyanobacteria were prepared using our eco-friendly approach. The G-tags possess high solubility, excellent photostability, and low cytotoxicity (<1.5 mg/mL for 24 h). Moreover, doxorubicin-conjugated G-tags (T-tags>0.1 mg/mL) induced death in cancer cells (HepG2 and MCF-7) in-vitro at a higher rate than that of only G-tags while in-vivo mice experiment showed enhanced anticancer efficacy by T-tags at 0.01 mg/mL, indicating that the loaded doxorubicin retains its pharmaceutical activity. The cancer cell uptake and intracellular location of the G- and T-tags were observed. The results indicate that these multifunctional T-tags can deliver doxorubicin to the targeted cancer cells and sense the delivery of doxorubicin by activating the fluorescence of G-tags.
URI
http://dx.doi.org/10.1038/srep04665
http://dspace.inha.ac.kr/handle/10505/53461
ISSN
2045-2322
Appears in Collections:
College of Engineering(공과대학) > Biotechnology (생명공학) > Journal Papers, Reports(생명공학 논문, 보고서)
Files in This Item:
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