An in vitro comparative study of T2 and T2* mappings of human articular cartilage at 3-Tesla MRI using histology as the standard of reference

Title
An in vitro comparative study of T2 and T2* mappings of human articular cartilage at 3-Tesla MRI using histology as the standard of reference
Authors
김학일
Keywords
MRI, Cartilage, Knee, Histology, Osteoarthritis, Biomarkers
Issue Date
2101-40-04
Publisher
SKELETAL RADIOLOGY
Series/Report no.
SKELETAL RADIOLOGY ; Vol43 no.7 Startpage 947 Endpage 954
Abstract
Objective The aim of this study was to evaluate the correlations between T2 value, T2* value, and histological grades of degenerated human articular cartilage. Materials and methods T2 mapping and T2* mapping of nine tibial osteochondral specimens were obtained using a 3-T MRI after total knee arthroplasty. A total of 94 ROIs were analyzed. Histological grades were assessed using the David–Vaudey scale. Spearman’s rho correlation analysis and Pearson’s correlation analysis were performed. Results The mean relaxation values in T2 map with different histological grades (0, 1, 2) of the cartilage were 51.9 ± 9.2 ms, 55.8 ± 12.8 ms, and 59.6 ± 10.2 ms, respectively. The mean relaxation values in T2* map with different histological grades (0, 1, 2) of the cartilage were 20.3 ± 10.3 ms, 21.1 ± 12.4 ms, and 15.4 ± 8.5 ms, respectively. Spearman’s rho correlation analysis confirmed a positive correlation between T2 value and histological grade (ρ = 0.313, p < 0.05). Pearson’s correlation analysis revealed a significant negative correlation between T2 and T2* (r = −0.322, p < 0.05). Although T2* values showed a decreasing trend with an increase in cartilage degeneration, this correlation was not statistically significant in this study (ρ = −0.192, p = 0.129). Conclusions T2 mapping was correlated with histological degeneration, and it may be a good biomarker for osteoarthritis in human articular cartilage. However, the strength of the correlation was weak (ρ = 0.313). Although T2* values showed a decreasing trend with an increase in cartilage degeneration, the correlation was not statistically significant. Therefore, T2 mapping may be more appropriate for the initial diagnosis of articular cartilage degeneration in the knee joint. Further studies on T2* mapping are needed to confirm its reliability and mechanism in cartilage degeneration.
URI
https://doi.org/10.1007/s00256-014-1872-z
http://dspace.inha.ac.kr/handle/10505/52381
ISSN
0364-2348
Appears in Collections:
College of Engineering(공과대학) > Information and Communication Engineering (정보통신공학) > Journal Papers, Reports(정보통신공학 논문, 보고서)
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