Glucose Sensors Using Lipoic Acid Self-Assembled Monolayers

Title
Glucose Sensors Using Lipoic Acid Self-Assembled Monolayers
Authors
김상섭
Keywords
Self-assembled monolayer, Glucose sensor, Thin film, Sol-gel
Issue Date
2014-10
Publisher
센서학회지
Series/Report no.
센서학회지; 23권 5호 pp 295~298
Abstract
A novel approach to fabricating high-performance glucose sensors is reported, which is based on the process of self-assembled monolayers (SAMs). In this study, we have particularly used α-lipoic acid (LA) SAMs for the glucose sensors. To our best knowledge, this study is the first one to use LA as SAMs for this purpose. N-hydroxysuccinimide (NHS) and 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) were deliberately attached at the same time on the LA SAM. Then, glucose oxidase (GOX) and horseradish peroxidase (HRP) were sequentially immobilized. Thus, the HRP/GOX/NHS-EDC/LA-SAM/Au/Cr/glass working electrode was developed. The glucose-sensing capability of the fabricated sensor was systematically measured by the use of cyclic voltammetry in the range of 1-30 mM glucose in phosphate-buffered saline. The result showed a good sensitivity, that is, as high as 27.5 μA/(mM·cm2 ). This result conspicuously demonstrates that LA can be one of promising substances for use as SAMs for accurately monitoring trace levels of glucose concentration in human blood.
URI
http://dspace.inha.ac.kr/handle/10505/39183
ISSN
1225-5475
Appears in Collections:
College of Engineering(공과대학) > Materials Science & Engineering (신소재공학) > Local Access Journal, Reports (신소재공학 논문, 보고서)

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