In vitro Antagonism between Cefotaxime and Anti- Rickettsial Antibiotics against Orientia tsutsugamushi

Title
In vitro Antagonism between Cefotaxime and Anti- Rickettsial Antibiotics against Orientia tsutsugamushi
Authors
이진수; 백지현
Keywords
Azithromycin, Cefotaxime, Drug combination, Doxycycline, Drug antagonism, Orientia tsutsugamushi, Scrub typhus
Issue Date
2014-01
Publisher
INFECTION AND CHEMOTHERAPY
Series/Report no.
INFECTION AND CHEMOTHERAPY; 46권 3호 pp 189~193
Abstract
We have investigated the in vitro antimicrobial effects of antibiotic combinations against Orientia tsutsugamushi, the causative agent of scrub typhus. ECV304 cells were infected with the Boryong strain of O. tsutsugamushi and incubated in a medium containing doxycycline (4 µg/mL), azithromycin (0.5 µg/mL), rifampin (4 µg/mL), ciprofloxacin (25 µg/mL), gentamicin (5 µg/mL), cefotaxime (2 µg/mL), or combinations of these agents for 7 days, after which immunofluorescent staining for O. tsutsugamushi was performed. The percentages of infective foci in cultures containing antibiotics compared to those in cultures without antibiotics were 6.2% for doxycycline, 9.6% for azithromycin, 8.8% for rifampin, 96.6% for cefotaxime, 29.7% for doxycycline plus cefotaxime, 23.6% for azithromycin plus cefotaxime, and 41.4% for rifampin plus cefotaxime. These findings show an in vitro antagonism between anti-rickettsial agents and cefotaxime against O. tsutsugamushi. These results suggest that the efficacy of antibiotic combinations involving cefotaxime for the treatment of patients with scrub typhus, particularly those with severe pneumonia, needs to be investigated.
URI
http://dspace.inha.ac.kr/handle/10505/38947
ISSN
2093-2340
Appears in Collections:
Medical School/College of Medicine (의학전문대학원/의과대학) > Medical Science (의학) > Local Access Journal Papers, Reports(의학 논문, 보고서)

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