A novel translocation involving RUNX1 and HOXA gene cluster in a case of acute myeloid leukemia with t(7;21)(p15;q22)

Title
A novel translocation involving RUNX1 and HOXA gene cluster in a case of acute myeloid leukemia with t(7;21)(p15;q22)
Authors
문연숙
Keywords
AML, Translocation, t(7;21), RUNX1, HOXA
Issue Date
2013
Publisher
IMMUNE NETWORK
Series/Report no.
IMMUNE NETWORK ; 제13권 제5호 pp 222~226
Abstract
Translocations involving chromosome 21q22 are frequently observed in hematologic malignancies including acute myeloid leukemia (AML), most of which have been known to be involved in malignant transformation through transcriptional dysregulation of Runt-related transcription factor 1 (RUNX1) target genes. Nineteen RUNX1 translocational partner genes, at least, have been identified, but not Homeobox A (HOXA) genes so far. We report a novel translocation of RUNX1 into the HOXA gene cluster in a 57-year-old female AML patient who had been diagnosed with myelofibrosis 39 months ahead. G-banding showed 46,XX,t(7;21)(p15;q22). The involvement of RUNX1 and HOXA genes was confirmed by fluorescence in situ hybridization.
URI
http://dx.doi.org/10.4110/in.2013.13.5.222
http://dspace.inha.ac.kr/handle/10505/33873
ISSN
1598-2629
Appears in Collections:
Medical School/College of Medicine (의학전문대학원/의과대학) > Medical Science (의학) > Local Access Journal Papers, Reports(의학 논문, 보고서)

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