The influence of previous antiosychotic polypharmacy versus monotherapy on the effectiveness of antiosychotic after switching to paliperidone Extended-Release

Title
The influence of previous antiosychotic polypharmacy versus monotherapy on the effectiveness of antiosychotic after switching to paliperidone Extended-Release
Authors
김철응
Keywords
Schizophrenia, Antipsychotic agents, Polypharmacy, 9-Hydroxyrisperidone, Treatment outcome
Issue Date
2013
Publisher
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
Series/Report no.
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE ; 제11권 제3호 pp 152~157
Abstract
Objective: Although antipsychotic polypharmacy is widely used in the pharmacotherapy of schizophrenia, its effectiveness is controversial. In particular, clinicians tend to avoid switching to monotherapy in patients who have been prescribed polypharmacy. In the present study, the authors investigate whether there is difference in time to discontinuation of antipsychotics between patients on previous monotherapy or polypharmacy. Methods: Pooled analysis was conducted on two 24-week, multicenter, open-label, non-comparative studies that were originally designed to investigate the effectiveness of switching to paliperidone extended-release (ER) in patients with schizophrenia. Patients were divided into two groups according to previously prescribed antipsychotics, that is, to a polypharmacy group or a monotherapy group. The primary outcome measure was time to discontinuation of paliperidone ER. In addition, the authors sought to identify clinical variables that influence time to discontinuation. Results: Before switching to paliperidone ER, 535 of 673 (79.5%) patients were prescribed antipsychotic monotherapy, and the remaining 138 (20.5%) patients were prescribed antipsychotic polypharmacy. No significant differences in time to discontinuation of paliperidone ER were observed between the polypharmacy and monotherapy groups. Personal and social performance scale score was the only factor found to influence time to discontinuation of paliperidone ER. No differences in psychopathology or adverse effects were found between the monotherapy and polypharmacy groups. Conclusion: Our results suggest that number of antipsychotics prescribed before switching to monotherapy does not influence clinical prognosis in patients with schizophrenia.
URI
http://dx.doi.org/10.9758/cpn.2013.11.3.152
http://dspace.inha.ac.kr/handle/10505/33868
ISSN
1738-1088
Appears in Collections:
Medical School/College of Medicine (의학전문대학원/의과대학) > Medical Science (의학) > Local Access Journal Papers, Reports(의학 논문, 보고서)

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