High In Vitro Infectivity of a Doxycycline-Insensitive Strain of Orientia tsutsugamushi

Title
High In Vitro Infectivity of a Doxycycline-Insensitive Strain of Orientia tsutsugamushi
Authors
강재승; 백지현
Keywords
Orientia tsutsugamushi, Scrub typhus, Virulence, Drug resistance
Issue Date
2013
Publisher
INFECTION AND CHEMOTHERAPY
Series/Report no.
INFECTION AND CHEMOTHERAPY ; 제45권 제4호 pp 431~434
Abstract
We compared the infectivity and growth rates of 12 strains of Orientia tsutsugamushi in a cell culture system. ECV304 cells were infected with O. tsutsugamushi strains for 4 hr, and the culture was maintained for 72 hr. Immunofluorescence (IF) staining was performed at 4, 24, 48, and 72 hr after inoculation (hpi), and IF-positive foci were enumerated. The AFSC-4 strain, which is known to be insensitive to doxycycline, showed higher numbers of IF-positive foci than the other 11 strains at 4, 24, 48, and 72 hpi, which may explain its apparent insensitivity to antibiotics.
URI
http://dx.doi.org/10.3947/ic.2013.45.4.431
http://dspace.inha.ac.kr/handle/10505/33840
ISSN
2093-2340
Appears in Collections:
Medical School/College of Medicine (의학전문대학원/의과대학) > Medical Science (의학) > Local Access Journal Papers, Reports(의학 논문, 보고서)

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