Caloric restriction and its mimetics

Title
Caloric restriction and its mimetics
Authors
민경진
Keywords
Caloric restriction, CR mimetics, Lifespan extension, Longevity
Issue Date
2013
Publisher
BMB REPORTS
Series/Report no.
BMB REPORTS ; Vol46 no.4 Startpage 181 Endpage 187
Abstract
Caloric restriction is the most reliable intervention to prevent age-related disorders and extend lifespan. The reduction of calories by 10-30% compared to an ad libitum diet is known to extend the longevity of various species from yeast to rodents. The underlying mechanisms by which the benefits of caloric restriction occur have not yet been clearly defined. However, many studies are being conducted in an attempt to elucidate these mechanisms, and there are indications that the benefits of caloric restriction are related to alteration of the metabolic rate and the accumulation of reactive oxygen species. During molecular signaling, insulin/insulin-like growth factor signaling, target of rapamycin pathway, adenosine monophosphate activated protein kinase signaling, and Sirtuin are focused as underlying pathways that mediate the benefits of caloric restriction. Here, we will review the current status of caloric restriction.
URI
http://dx.doi.org/10.5483/BMBRep.2013.46.4.033
http://dspace.inha.ac.kr/handle/10505/33219
ISSN
1976-6696
Appears in Collections:
College of Natural Science(자연과학대학) > Biological Sciences (생명과학) > Local Access Journal Papers, Reports(생명과학 논문, 보고서)

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