Assessment of Spirulina-PCL nanofiber for the regeneration of dermal fibroblast layers

Title
Assessment of Spirulina-PCL nanofiber for the regeneration of dermal fibroblast layers
Authors
신화성
Keywords
Spirulina . Nanofiber . Skin regeneration . Antioxidant . Infiltration . Tissue engineering
Issue Date
2013
Publisher
IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
Series/Report no.
IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL; vol.49 startpage 27 endpage 33
Abstract
Skin is a barrier which protects injured tissues, and thus, skin regeneration is one of many important medical issues. Tissue engineering is an attractive approach to make artificial tissue or regenerate lost tissues. While constituting artificial tissues, cells must infiltrate through scaffolds, maintaining viability and proliferation. However, a three-dimensional tissue culture involves stressful environments due to several reasons such as mass or gas transport and high cell density. Once stressed, cells produce reactive oxygen species, resulting in alleviating cellular viability and activity. Spirulina is well known to have antioxidant molecules, which have been known to modulate oxidative stress to cells. Electrospun nanofiber has widely been used as a scaffold to mimic natural extracellular matrix. In this research, we assessed Spirulina extract-imbedded nanofiber as a scaffold for an artificial skin tissue. Spirulina extract was proven to positively affect viability and proliferation of mouse fibroblasts. In addition, fibroblasts infiltrated through Spirulina extract-imbedded electrospun nanofiber without cytotoxicity.
URI
http://dspace.inha.ac.kr/handle/10505/32538
ISSN
1071-2690
Appears in Collections:
College of Engineering(공과대학) > Biotechnology (생명공학) > Journal Papers, Reports(생명공학 논문, 보고서)
Files in This Item:
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