We report a 67-year-oldman who presented with severe headache after taking 50mg of
udenafil, a new phosphodiesterase 5 inhibitor. Computed tomographic imaging of the
brain revealed a small amount of acute subarachnoid hemorrhage localized around
basal cisterns (anterior to midbrain and pons). There were no aneurysms in the
cerebral arteries, although vein of Galen stenosis was suspected after magnetic resonance
venography. This case anecdotally suggests that phosphodiesterase 5 inhibition
might trigger perimesencephalic subarachnoid hemorrhage with venous hypertension
possibly associated with vein of Galen stenosis. Key Words: Cerebral veins?
phosphodisesterase 5 inhibitors?subarachnoid hemorrhage?udenafil.
2013 by National Stroke Association