Interaction of white matter hyperintensities (WMHs) and apolipoprotein E (APOE) genotypes on cognition in patients with amnestic mild cognitive impairment (aMCI).

Title
Interaction of white matter hyperintensities (WMHs) and apolipoprotein E (APOE) genotypes on cognition in patients with amnestic mild cognitive impairment (aMCI).
Authors
최성혜
Keywords
WMHs APOE Mild cognitive impairment Frontal executive function Cognition
Issue Date
2013
Publisher
ARCHIVES OF GERONTOLOGY AND GERIATRICS
Series/Report no.
ARCHIVES OF GERONTOLOGY AND GERIATRICS ; Vol.57 no.3 Startpage 292 Endpage 297
Abstract
The clinical implications of WMHs in aMCI are inconclusive. Moreover, clinical interactions between APOE genotypes and WMHs remain unclear. This study was conducted to investigate the relationship between WMHs and cognitive functions and how this relationship interacted with APOE genotype in people with aMCI. This study included a total of 1472 patients with aMCI from the Clinical Research Center for Dementia of South Korea (CREDOS) and divided them into 3 groups according to the severity of WMHs as assessed by visual ratings of brain magnetic resonance images. The associations of WMHs with the various cognitive domains and with APOE epsilon 4 (e4) status were evaluated. After multivariable adjustments, the severity of WMHs was independently associated with semantic/phonemic verbal fluency and Stroop test-color reading, while APOE e4 status was associated with verbal and visual memory-immediate, delayed recall, and recognition. Moreover, there were interaction between WMHs and APOE e4 status in semantic verbal fluency (animal, P = 0.033; supermarket, P = 0.047)/Stroop testcolor reading (P = 0.024). WMHs independently deleteriously affected frontal executive functions in aMCI patients, regardless of APOE e4 presence. Furthermore, APOE e4 possession caused a rapid decline in frontal executive functions with the increase in the WMHs severity (vs. absence), suggesting that WMHs and APOE e4 genotypes synergistically contribute to frontal executive dysfunctions in aMCI.
URI
http://dx.doi.org/10.1016/j.archger.2013.04.008
http://dspace.inha.ac.kr/handle/10505/31912
ISSN
0167-4943
Appears in Collections:
Medical School/College of Medicine (의학전문대학원/의과대학) > Medical Science (의학) > Journal Papers, Reports(의학 논문, 보고서)
Files in This Item:
33531.pdfDownload

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse