Ninjurin1 deficiency attenuates susceptibility of experimental autoimmune encephalomyelitis in mice

Title
Ninjurin1 deficiency attenuates susceptibility of experimental autoimmune encephalomyelitis in mice
Authors
류지간
Issue Date
2014
Publisher
JOURNAL OF BIOLOGICAL CHEMISTRY
Series/Report no.
JOURNAL OF BIOLOGICAL CHEMISTRY ; Vol.289 no.6 Startpage 3328 Endpage 3338
Abstract
Background: Effect of Ninjurin1 deletion in the experimental autoimmune encephalomyelitis (EAE) mice has not been examined. Results: Ninjurin1 knock-out (KO) mice are resistance to EAE due to a defect of leukocyte recruitment into lesion sites. Conclusion: Ninjurin1 is a potent target molecule for treating inflammatory diseases such as multiple sclerosis. Significance: Our study proved contribution of Ninjurin1 in EAE pathogenesis in vivo and supports the importance of its targeting strategies.
URI
http://dspace.inha.ac.kr/handle/10505/31706
ISSN
0021-9258
Appears in Collections:
Medical School/College of Medicine (의학전문대학원/의과대학) > Medical Science (의학) > Journal Papers, Reports(의학 논문, 보고서)

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