Changes in subfoveal choroidal thickness and choroidal extravascular density by spectral domain optical coherence tomography after haemodialysis : a pilot study

Title
Changes in subfoveal choroidal thickness and choroidal extravascular density by spectral domain optical coherence tomography after haemodialysis : a pilot study
Authors
진희승
Issue Date
2014
Publisher
BRITISH JOURNAL OF OPHTHALMOLOGY
Series/Report no.
BRITISH JOURNAL OF OPHTHALMOLOGY ; Vol.98 no.S01 Startpage 207 Endpage 212
Abstract
Aims To examine the changes in the subfoveal choroidal thickness (SFCT) and choroidal density using spectral domain optical coherence tomography (SD-OCT) before and after haemodialysis (HD). Methods 28 eyes of 19 patients with chronic renal failure (CRF) undergoing HD were included. Ophthalmologic examinations including SD-OCT were performed 1 h before and after HD. The SFCT was measured manually using Image J software, and the relationships between the change in SFCT and in the systemic parameters after HD were evaluated. The changes in choroidal extravascular density of the OCT image after HD were evaluated by comparing brightness value obtained with Adobe Photoshop software. Results The mean SFCT of all eyes increased significantly from 276.94±58.73 mm to 288.29 ±65.57 mm (p=0.003). In the univariate generalised estimating equation (GEE), the SFCT increased significantly after HD (p=0.006). After adjusting for age, gender and other significant factors in univariate analysis, the SFCT increased significantly after HD (p=0.032). The decrease in systolic blood pressure (SBP) was associated with the increase in SFCT (p=0.013). The choroidal extravascular density of OCT image increased after HD (p<0.001) and the mean change was 12.35±9.72. Conclusions In the SD-OCT image, the SFCT became thicker and the choroidal extravascular density increased after HD in patients with CRF. The decrease in SBP after HD was associated with an increase in SFCT. The choroidal autoregulatory control of ocular hemodynamic change and shifting of fluid and molecules between the blood and choroidal interstitium might be involved in the mechanism of these choroidal changes.
URI
http://dspace.inha.ac.kr/handle/10505/31640
ISSN
0007-1161
Appears in Collections:
Medical School/College of Medicine (의학전문대학원/의과대학) > Medical Science (의학) > Journal Papers, Reports(의학 논문, 보고서)
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