The effect of duodenojejunal bypass for type 2 diabetes mellitus patients below body mass index 25㎏/㎡: one year follow-up

Title
The effect of duodenojejunal bypass for type 2 diabetes mellitus patients below body mass index 25㎏/㎡: one year follow-up
Authors
신석환
Keywords
Type 2 diabetes mellitus, Metabolic surgery, Duodenojejunal bypass
Issue Date
2013
Publisher
JOURNAL OF THE KOREAN SURGICAL SOCIETY
Series/Report no.
JOURNAL OF THE KOREAN SURGICAL SOCIETY ; Vol.85 no.3 Startpage 109 Endpage 115
Abstract
Purpose: The goals of this study are to evaluate the effect of duodenojejunal bypass (DJB) for type 2 diabetes mellitus (T2DM) patients below body mass index (BMI) 25 kg/m2 in one year follow-up, and to compare the results of 1 week which we have reported in 2011. Methods: In this prospective observational study, there were 31 type 2 diabetic patients who underwent DJB at Inha University Hospital from July 2009 to January 2011. We did laboratories such as 75-g oral glucose tolerance test (OGTT), insulin level and hemoglobin A1c (HbA1c), etc. and compared their changes of preoperative, a week, 3 months, and 12 months. Results: Mean BMI was 23.1 ± 1.3 kg/m2 , mean duration of T2DM was 8.3 ± 4.7 and mean age was 46.6 ± 7.7 years. There were a significant decrease of 75-g OGTT levels and increase of insulin secretion after 3 months. 13.3% showed diabetic remission (HbA1c < 6.0, medication cessation) and 26.7% showed diabetic improvement. The rates of remission and improvement much declined comparing with that of postoperative 1 week although those were determined by fasting and postprandial 2 hour level of glucose. Conclusion: This is the first study of metabolic surgery in Korean diabetes patients in the healthy weight range. DJB exerted positive influences on insulin resistance as well as beta cell function. Early effects on T2DM after DJB could be estimated as one of good modalities, although the effectiveness seems to be unacceptable. Further studies are mandatory for evaluation of the effectiveness of metabolic surgery and finding prognostic factors.
URI
http://dx.doi.org/10.4174/jkss.2013.85.3.109
http://dspace.inha.ac.kr/handle/10505/31544
ISSN
2233-7903
Appears in Collections:
Medical School/College of Medicine (의학전문대학원/의과대학) > Medical Science (의학) > Journal Papers, Reports(의학 논문, 보고서)

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