Maintenance of CMV-specific CD8+ T cell responses and the relationship of IL-27 to IFN-γ levels with aging

Title
Maintenance of CMV-specific CD8+ T cell responses and the relationship of IL-27 to IFN-γ levels with aging
Authors
이진수
Keywords
CD8+ T cells IL-27 Human Aging Cytomegalovirus (CMV)
Issue Date
2013
Publisher
CYTOKINE
Series/Report no.
CYTOKINE ; Vol.61 no.2 Startpage 485 Endpage 490
Abstract
We investigated whether healthy young (age 6 40) and elderly (ageP65) people infected with cytomegalovirus (CMV) had similar levels of CD8+ T cell cytokine production and proliferation in response to an immunodominant CMV pp65 peptide pool given the role of CD8+ T cells in controlling viral infection and the association of CMV with immunosenescence. Plus, we determined the effects of aging and CMV-infectious status on plasma levels of IL-27, an innate immune cytokine with pro- and anti-inflammatory properties, as well as on its relationship to IFN-c in that IL-27 can promote the production of IFN-c. The results of our study show that young and elderly people had similar levels of CD8+ T cell proliferation, and IFN-c and TNF-a production in response to CMV pp65 peptides. Plasma levels of IL-27 were similar between the two groups although CMV-infected young and elderly people had a trend toward increased levels of IL- 27. Regardless of aging and CMV-infectious status, plasma levels of IL-27 correlated highly with plasma levels of IFN-c. These findings suggest the maintenance of CMV pp65-specific CD8+ T cell proliferation and cytokine production with aging as well as the sustaining of circulatory IL-27 levels and its biological link to IFN-c in young and elderly people irrespective of CMV infection.
URI
http://dx.doi.org/10.1016/j.cyto.2012.11.024
http://dspace.inha.ac.kr/handle/10505/31446
ISSN
1043-4666
Appears in Collections:
Medical School/College of Medicine (의학전문대학원/의과대학) > Medical Science (의학) > Journal Papers, Reports(의학 논문, 보고서)
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