Poly(l-aspartic acid) nanogels for lysosome-selective antitumor drug delivery.

Title
Poly(l-aspartic acid) nanogels for lysosome-selective antitumor drug delivery.
Authors
이돈행
Keywords
Poly(l-aspartic acid) derivative nanogels 3-Diethylaminopropyl pH-sensitive nanogels Lysosomal pH Tumor therapy
Issue Date
2013
Publisher
COLLOIDS AND SURFACES B:BIOINTERFACES
Series/Report no.
COLLOIDS AND SURFACES B:BIOINTERFACES ; Vol.101 Startpage 298 Endpage 306
Abstract
Advanced materials that have controllable pH-responsive properties when submerged in the lysosome have a great potential in intracellular drug delivery. We developed novel poly(l-amino acid) nanogels that were prepared by a facile cross-linking of poly[l-aspartic acid-g-(3-diethylaminopropyl)]- b-poly(ethylene glycol)-maleimide [poly(l-Asp-g-DEAP)-b-PEG-Mal] and poly(l-aspartic acid-g-ethyl thiol)-b-PEG [poly(l-Asp-SH)-b-PEG] in an oil/water emulsion condition. Interestingly, these nanogels (∼125 nm in diameter) modulated volume expansion (∼375 nm in diameter) in a lysosomal pH (∼pH 5.0) due to an extensive proton absorption of DEAP at a low pH, which mediated lysosome swelling and the subsequent lysosome destabilization. In the in vitro tumor cell cytotoxicity test, they encouraged tumor cell death, probably owing to the leakage of lysosomal enzymes. Furthermore, encapsulating antitumor drug (e.g., doxorubicin, DOX) into these nanogels enhanced tumor cell cytotoxicity. We conclude that this nanogel system will have great potential for tumor therapy.
URI
http://dx.doi.org/10.1016/j.colsurfb.2012.07.013
http://dspace.inha.ac.kr/handle/10505/31375
ISSN
0927-7765
Appears in Collections:
Medical School/College of Medicine (의학전문대학원/의과대학) > Medical Science (의학) > Journal Papers, Reports(의학 논문, 보고서)
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