Enhancement of mitochondrial function correlates with the extension of lifespan by caloric restriction and caloric restriction mimetics in yeast.

Title
Enhancement of mitochondrial function correlates with the extension of lifespan by caloric restriction and caloric restriction mimetics in yeast.
Authors
이성근
Keywords
Caloric restriction Caloric restriction mimetics Rapamycin Reactive oxygen species Mitochondrial membrane potential ATP
Issue Date
2013
Publisher
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Series/Report no.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS ; Vol.441 no.1 Startpage 236 Endpage 242
Abstract
Caloric restriction mimetics (CRMs) have been developed to mimic the effects of caloric restriction (CR). However, research reports for the effects of CRMs are often times inconsistent across different research groups. Therefore, in this study, we compared seven identified CRMs which extend the lifespans of various organisms including caffeine, curcumin, dapsone, metformin, rapamycin, resveratrol, and spermidine to CR for mitochondrial function in a single model, Saccharomyces cerevisiae. In this organism, rapamycin extended chronological lifespan (CLS), but other CRMs failed to extend CLS. Rapamycin enhanced mitochondrial function like CR did, but other CRMs did not. Both CR and rapamycin worked on mitochondrial function, but they worked at different windows of time during the chronological aging process.
URI
http://dx.doi.org/10.1016/j.bbrc.2013.10.049
http://dspace.inha.ac.kr/handle/10505/31305
ISSN
0006-291X
Appears in Collections:
Medical School/College of Medicine (의학전문대학원/의과대학) > Medical Science (의학) > Journal Papers, Reports(의학 논문, 보고서)
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