비소세포폐암환자에서 표피성장인자수용체-티로신키나아제억제제 치료 후 관류영상 : 예비연구

Title
비소세포폐암환자에서 표피성장인자수용체-티로신키나아제억제제 치료 후 관류영상 : 예비연구
Authors
이주원
Keywords
비소세포폐암환자에서표피성장인자수용체티로신키나아제억제제치료후관류영상예비연구
Issue Date
2012
Publisher
인하대학교
Abstract
Purpose To quantify the anti-angiogenic effect of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) by mapping perfusion parameters on a voxel-by-voxel basis using dynamic contrast enhanced (DCE) magnetic resonance imaging (MRI) in patients with non-small cell lung cancer (NSCLC). Materials and methods Five patients were prospectively enrolled, satisfying the following criteria: 1) patients with pathologically-proven recurrent or metastatic NSCLC; 2) patients with primary masses of more than 3 cm along the longest diameter; and 3) patients with EGFR mutations or at least 2 of the following factors, adenocarcinoma, female, or never-smokers. Patients were treated with gefitinib or erlotinib and the start of chemotherapy was denoted Day 0 (D0). DCE-MRI was performed at Day-1 (D-1), Day+7 (D+7), and Day+28 (D+28). Perfusion parameters were calculated using extended Kety model. Dynamic curve pattern was analyzed with time-concentration curve for the lung cancer region
Description
Abstract 1 Introduction 4 Methods 6 Patient selection 6 DCE-MRI acquisition 7 Data analyses 8 Response assessment 10 Statistical analysis 11 Results 11 Patients' characteristics 12 Longitudinal changes in perfusion parameters 12 Response assessment 13 Discussion 14 References 17 Tables 23 Figure and legends 26
URI
http://dspace.inha.ac.kr/handle/10505/23478
Appears in Collections:
Medical School/College of Medicine (의학전문대학원/의과대학) > Medical Science (의학) > Theses(의학 석박사 학위논문)
Files in This Item:
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