Streptozotocin 으로 유도된 1형 당뇨 마우스 모델에서 Ninjurin1 차단 항체의 음경해면체내피세포 재생 및 발기력 개선 효과

Title
Streptozotocin 으로 유도된 1형 당뇨 마우스 모델에서 Ninjurin1 차단 항체의 음경해면체내피세포 재생 및 발기력 개선 효과
Authors
윤국남
Keywords
streptozotocin으로유도된1형당뇨마우스모델에서ninjurin1차단항체의음경해면체내피세포재생및발기력개선효과
Issue Date
2012
Publisher
인하대학교
Abstract
Objectives: Patients with diabetic erectile dysfunction (ED) often have severe endothelial dysfunction and peripheral nerve damage, which results in poor response to oral phosphodiesterase-5 inhibitors. Nerve injury-induced protein 1 (Ninjurin 1) has been known to be up-regulated after peripheral nerve injury and to be involved in vascular regression during embryonic period. In the present study, we examined differential expression of Ninjurin 1 in the penis of diabetic mice and also determined whether and how Ninjurin 1 blocking antibody restores erectile function in diabetic animals. Methods: Eight-week-old C57BL/6J mice were used and diabetes was induced by intraperitoneal injection of streptozotocin (50 mg/kg/d for 5 days). At 8 weeks after induction of diabetes, the animals were divided into 5 groups (N = 10 per group): controls, diabetic mice, and diabetic mice treated with a single intracavernous injection of PBS (20 ?l) or Ninjurin 1 blocking antibody (1.0 ?g or 2.5 ?g/20 ?l,
Description
Introduction 1 Methods 6 Results 17 Figures 25 Discussion 43 Conclusion 49 References 50
URI
http://dspace.inha.ac.kr/handle/10505/23464
Appears in Collections:
Medical School/College of Medicine (의학전문대학원/의과대학) > Medical Science (의학) > Theses(의학 석박사 학위논문)
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