The Syntheses of 3-substituted 4-(pyridin-2-ylthio)indoles via Leimgruber-Batcho indole synthesis

Title
The Syntheses of 3-substituted 4-(pyridin-2-ylthio)indoles via Leimgruber-Batcho indole synthesis
Authors
Chi, D.Y.
Keywords
heterocyclic sulfide, indole synthesis
Issue Date
2004
Publisher
KOREAN CHEMICAL SOC
Abstract
We have designed a new family of radioligands, 3-(amino- and hydroxymethyl)-4-(5-iodopyridin-2-ylthio)indoles, combining characteristically distinct moieties proven to impart successful binding ability in a variety of structurally diverse selective serotonin reuptake inhibitors recently published. Described in this article are the syntheses of 3-substituted 4-(5-iodopyridin-2-ylthio)-indoles, featuring successful adaptation of the modified Leimgruber-Batcho indole synthesis onto the key intermediate 1-(5-iodopyridin-2-ylthio)-2-methyl-3-nitrobenzene (6) prepared from the nucleophilic aromatic substitution of chloropyridine 7 with thiophenol 8.
URI
http://dspace.inha.ac.kr/handle/10505/20382
ISSN
0253-2964
Appears in Collections:
College of Natural Science(자연과학대학) > Chemistry (화학) > Journal Papers, Reports(화학 논문, 보고서)
Files in This Item:
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