Metabolic stability of [18F]fluoroalkylbiphenyls

Title
Metabolic stability of [18F]fluoroalkylbiphenyls
Authors
Chi, D.Y.
Keywords
metabolism study, fluoroalkyl
Issue Date
2004-08
Publisher
KOREAN CHEMICAL SOC
Abstract
The stability of fluoroalkyl groups as a pendent on the phenyl ring was measured in vitro using rat hepatic microsomes and human serum to predict their in vivo stabilities. We have prepared three [F-18]fluoroalkylbiphenyls as the model compounds of fluoroalkyl aromatic compounds to compare the in vitro stabilities. In addition, in vitro stabilities were measured separately using rat hepatic microsomes and human serum at 37 degreesC. Fluoroethylbiphenyl had similar or slightly superior stability to fluoropropylbiphenyl and these two compounds were much more stable than fluoromethylbiphenyl in vitro.
URI
http://dspace.inha.ac.kr/handle/10505/20380
ISSN
0253-2964
Appears in Collections:
College of Natural Science(자연과학대학) > Chemistry (화학) > Journal Papers, Reports(화학 논문, 보고서)
Files in This Item:
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