4-Aminopyridine (4-AP) Augments Ca2+-dependent Action Potential and Changes Oscillatory Firing Patterns in Rat Cerebellar Purkinje Cells

Title
4-Aminopyridine (4-AP) Augments Ca2+-dependent Action Potential and Changes Oscillatory Firing Patterns in Rat Cerebellar Purkinje Cells
Authors
Shin, JH.; Suh, CK.; Seo, WS.
Keywords
ELECTRO-PHYSIOLOGICAL PROPERTIES, NEURONS
Issue Date
1999-04
Publisher
YONSEI UNIV COLLEGE MEDICINE
Abstract
Intracellular recordings in cerebellar slice preparation showed that applications of 4-AP altered the pattern of oscillatory firing activity in Purkinje cells (PCs), especially yielding pronounced changes in action potential shape. 4-AP increased the amplitude and duration of action potential significantly and decreased the spike frequency. After 4-AP application, the duration of bursting was prolonged and the duration of after-burst hyperpolarization was progressively shortened. In all PCs tested, the rhythmicity of oscillatory firing activity was abolished completely at the steady state. These results suggest that 4-AP-sensitive currents determine the shape and frequency of individual Ca2+-dependent action potentials as well as maintaining oscillatory firing activity in PG.
URI
http://dspace.inha.ac.kr/handle/10505/20338
ISSN
0513-5796
Appears in Collections:
Medical School/College of Medicine (의학전문대학원/의과대학) > Medical Science (의학) > Journal Papers, Reports(의학 논문, 보고서)
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