Modeling of Inhibition Mechanism of Natural Ligands to Farnesyl Protein Transferase Using Molecular Docking

Title
Modeling of Inhibition Mechanism of Natural Ligands to Farnesyl Protein Transferase Using Molecular Docking
Authors
Kim, C.K.; Park, H.Y.
Keywords
molecular modeling, molecular docking
Issue Date
2003-10
Publisher
KOREAN CHEMICAL SOC
Abstract
Ras Proteins play important roles in the signal transduction necessary for the cell growth. In the tumour cells, approximately 30% of the Ras protein genes are mutated. Ras proteins (H, N, and K) are small guanine nucleotide binding proteins that undergo a series of post-translational modifications including the farnesylation on the thiol group at the Ras C-terminus catalyzed by the farnesyl protein transferase (FPTase).
URI
http://dspace.inha.ac.kr/handle/10505/20330
ISSN
0253-2964
Appears in Collections:
College of Natural Science(자연과학대학) > Chemistry (화학) > Journal Papers, Reports(화학 논문, 보고서)
Files in This Item:
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