Effect of peritoneal glucose load on plasma leptin concentration in continuous ambulatory peritonal dialysis patients

Title
Effect of peritoneal glucose load on plasma leptin concentration in continuous ambulatory peritonal dialysis patients
Authors
Hyun, I.Y.
Keywords
leptin, glucose
Issue Date
2000-06
Publisher
YONSEI MEDICAL JOURNAL
Abstract
This study was performed to investigate the effect of peritoneal glucose load on plasma leptin concentrations in the continuous ambulatory peritoneal dialysis (CAPD) performed on 13 non-diabetic ESRD patients. Plasma leptin and insulin concentrations were measured for 2 hours during a single 2 liter exchange of 1.5% glucose-based dialysate (SPD, n=6), for 7 days of daily peritoneal dialysis (DPD, n=7). In DPD, standard full volume (2,000 mlX4 times/day) exchange was performed immediately after operation. In SPD, plasma leptin and insulin concentrations remained unchanged during the study. In DPD, the plasma leptin concentration increased significantly after CAPD on the first day (PD1) (11.2+/-5.4 to 17.0+/-6.0 ng/mL, p<0.05) and this elevation seemed to persist until 7 days after operation. After CAPD, there was no significant day-to-day variation in peritoneal glucose absorption (391-465 cal). Oral intake seemed to decrease on operation day (PD0) and PD1 and then increased slowly. Plasma insulin and glucose concentrations did not significantly change after CAPD. Changes of leptin concentration were significantly correlated with the changes of peritoneal glucose absorption at PD1. In conclusion, continuous peritoneal glucose load may affect plasma leptin concentrations in CAPD patients.
URI
http://dspace.inha.ac.kr/handle/10505/20175
ISSN
0513-5796
Appears in Collections:
Medical School/College of Medicine (의학전문대학원/의과대학) > Medical Science (의학) > Journal Papers, Reports(의학 논문, 보고서)
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