Statin-induced myopathy in skeletal muscle: the role of exercise

Title
Statin-induced myopathy in skeletal muscle: the role of exercise
Authors
곽효범
Keywords
Statins, Myopathy, Exercise, Skeletal muscle
Issue Date
2014-12
Publisher
JOURNAL OF LIFESTYLE MEDICINE
Series/Report no.
JOURNAL OF LIFESTYLE MEDICINE ; 4권 2호 pp 71~79
Abstract
Statins are widely used drugs to lower cholesterol levels and to reduce the risk of cardiovascular disease. However, it has been reported that statins are associated with adverse side effects of skeletal myopathy. Statin treatment can impair mitochondrial function and induce apoptosis in skeletal muscle in both human and animal models. Ubiquinone plays an essential role in transferring electrons in the mitochondrial electron transfer chain for oxidative phosphorylation. However, statin treatment reduces ubiquinone levels in the cholesterol synthesis pathway, which may be associated with mitochondrial dysfunction. In addition, reactive oxygen species (ROS) production and apoptosis induced by statins may provide cellular and molecular mechanisms in skeletal myopathy. Exercise is the most effective therapy to prevent metabolic and cardiovascular diseases. However, whether exercise provides a benefit to or exacerbation of statin-induced myopathy in skeletal muscle remains poorly investigated. This review will briefly provide a comprehensive summary regarding the effects of statins on skeletal myopathy, and discuss the potential mechanisms of statin-induced myopathy and the role of exercise in statin-induced myopathy in skeletal muscle.
URI
http://dx.doi.org/10.15280/jlm.2014.4.2.71
http://dspace.inha.ac.kr/handle/10505/39714
ISSN
2288-1557
Appears in Collections:
School of Arts & Sports(예술체육학부) > Kinesiology (스포츠과학) > Local Access Journal Papers (스포츠과학_학술논문)

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