Effects of interventions on adiponectin and adiponectin receptors

Title
Effects of interventions on adiponectin and adiponectin receptors
Authors
곽효범
Keywords
Pharmacological agents, Exercise, Calorie restriction, Adiponectin, Adiponectin receptors
Issue Date
2014-04
Publisher
Journal of exercise rehabilitation
Series/Report no.
Journal of exercise rehabilitation ; 10권 2호 pp 60~68
Abstract
Adiponectin secreted from adipose tissue binds to two distinct adiponectin receptors (AdipoR1 and AdipoR2) identified and exerts its anti-diabetic effects in insulin-sensitive organs including liver, skeletal muscle and adipose tissue as well as amelioration of vascular dysfunction in the various vasculatures. A number of experimental and clinical observations have demonstrated that circulating levels of adiponectin are markedly reduced in obesity, type 2 diabetes, hypertension, and coronary artery disease. Therapeutic interventions which can improve the action of adiponectin including elevation of circulating adiponectin concentration or up-regulation and/or activation of its receptors, could provide better understanding of strategies to ameliorate metabolic disorders and vascular disease. The focus of the present review is to summarize accumulating evidence showing the role of interventions such as pharmacological agents, exercise, and calorie restriction in the expression of adiponectin and adiponectin receptors.
URI
http://dx.doi.org/10.12965/jer.140104
http://dspace.inha.ac.kr/handle/10505/39713
ISSN
1976-6319
Appears in Collections:
School of Arts & Sports(예술체육학부) > Kinesiology (스포츠과학) > Local Access Journal Papers (스포츠과학_학술논문)

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse