Role of adiponectin in metabolic and cardiovascular disease

Title
Role of adiponectin in metabolic and cardiovascular disease
Authors
곽효범
Keywords
Adiponectin receptors, AdipoRON, AMPK, PPARα
Issue Date
2014-04
Publisher
Journal of exercise rehabilitation
Series/Report no.
Journal of exercise rehabilitation ; 10권 2호 pp 54~59
Abstract
Under disease conditions including obesity (insulin resistance) and diabetes, dysregulation of adipokines such as tumor necrosis factor (TNF)-α, leptin, resistin, and adiponectin contribute to the development of metabolic and cardiovascular disease. Unlike other adipokines, adiponectin has been shown to be a therapeutic target for metabolic syndrome and cardiovascular disease. Circulating levels of adiponectin are markedly reduced in obese, diabetic, hypertensive, and coronary artery disease patients as well as experimental animal models of insulin resistance and diabetes. Recently, the small molecule adiponectin receptors (AdipoRs) agonist was discovered and suggested that the agonist is a novel therapeutic target for the treatment of type 2 diabetes linked to obesity in an experimental mouse model. This review will focus on signaling pathways involved in adiponectin and its receptors and the role of adiponectin in metabolic and cardiovascular disease including insulin resistance, cardiomyopathy, and cardiovascular dysfunction.
URI
http://dx.doi.org/10.12965/jer.140100
http://dspace.inha.ac.kr/handle/10505/39712
ISSN
1976-6319
Appears in Collections:
School of Arts & Sports(예술체육학부) > Kinesiology (스포츠과학) > Local Access Journal Papers (스포츠과학_학술논문)

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