Overexpression of transforming growth factor-beta 1 in the valvular fibrosis of chronic rheumatic heart disease

Title
Overexpression of transforming growth factor-beta 1 in the valvular fibrosis of chronic rheumatic heart disease
Authors
Kim, L.; Kim, D.K.; Yang, W.I.; Shin, D.H.; Jung, I.M.; Park, H.K.; Chang, B.C.
Keywords
rheumatic heart disease, transforming growth factor-beta 1, fibrosis
Issue Date
2008-02
Publisher
KOREAN ACAD MEDICAL SCIENCES
Abstract
For the purpose of determining the pathogenic role of transforming growth factor-beta 1 (TGF-beta 1) in the mechanism of chronic rheumatic heart disease, we evaluated the expression of TGF-beta 1, proliferation of myofibroblasts, and changes in extracellular matrix components including collagen and proteoglycan in 30 rheumatic mitral valves and in 15 control valves. High TGF-beta 1 expression was identified in 21 cases (70%) of rheumatic mitral valves, whereas only 3 cases (20%) of the control group showed high TGF-beta 1 expression (p<0.001). Additionally, increased proliferation of myofibroblasts was observed in the rheumatic valves. High TGF-beta 1 expression positively correlated with the proliferation of myofibroblasts (p=0.004), valvular fibrosis (p<0.001), inflammatory cell infiltration (p=0.004), neovascularization (p=0.007), and calcification (p<0.001) in the valvular leaflets. The ratio of proteoglycan to collagen deposition inversely correlated with TGF-beta 1 expression in mitral valves (p=0.040). In conclusion, an ongoing inflammatory process, the expression of TGF-beta 1, and proliferation of myofibroblasts within the valves have a potential role in the valvular fibrosis, calcification, and changes in the extracellular matrix that lead to the scarring sequelae of rheumatic heart disease.
URI
http://dspace.inha.ac.kr/handle/10505/1956
ISSN
1011-8934
Appears in Collections:
Medical School/College of Medicine (의학전문대학원/의과대학) > Medical Science (의학) > Journal Papers, Reports(의학 논문, 보고서)
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