Maternal stress produces learning deficits associated with impairment of NMDA receptor-mediated synaptic plasticity

Title
Maternal stress produces learning deficits associated with impairment of NMDA receptor-mediated synaptic plasticity
Authors
Jo, J.H.; Lee, C.J.
Keywords
maternal stress, hippocampus, learning and memory, synaptic plasticity
Issue Date
2006-03
Publisher
SOC NEUROSCIENCE
Abstract
Stress in adulthood can have a profound effect on physiology and behavior, but the extent to which prolonged maternal stress affects the brain function of offspring when they are adult remains primarily unknown. In the present work, chronic immobilization stress to pregnant mice affected fetal growth and development. When pups born from stressed mice were reared to adulthood in an environment identical to that of nonstressed controls, several physiological parameters were essentially unaltered. However, spatial learning and memory was significantly impaired in the maternally stressed offspring in adulthood. Furthermore, electrophysiological examination revealed a significant reduction in NMDA receptor-mediated long-term potentiation in the CA1 area of hippocampal slices. Subsequent biochemical analysis demonstrated a substantial decrease in NR1 and NR2B subunits of the NMDA receptor in synapses of the hippocampus, and the interaction between these two subunits appeared to be reduced. These results suggest that prolonged maternal stress leads to long-lasting malfunction of the hippocampus, which extends to and is manifested in adulthood.
URI
http://dspace.inha.ac.kr/handle/10505/1588
ISSN
0270-6474
Appears in Collections:
College of Natural Science(자연과학대학) > Biological Sciences (생명과학) > Journal Papers, Reports(생명과학 논문, 보고서)
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