Celecoxib induces hepatic stellate cell apoptosis through inhibition of Akt activation and suppresses hepatic fibrosis in rats

Title
Celecoxib induces hepatic stellate cell apoptosis through inhibition of Akt activation and suppresses hepatic fibrosis in rats
Authors
Lee, J.I.
Keywords
SELECTIVE CYCLOOXYGENASE-2 INHIBITORS, EXPERIMENTAL LIVER FIBROSIS, COX-2 INHIBITOR
Issue Date
2009-11
Publisher
BMJ Publishing Group
Abstract
Activated hepatic stellate cells (HSCs) but not quiescent HSCs express cyclo-oxygenase-2 (COX-2), suggesting that the COX-2/prostanoid pathway has an active role in hepatic fibrogenesis. However, the role of COX-2 inhibitors in hepatic fibrogenesis remains controversial. The aim of this study was to investigate the antifibrotic effects of celecoxib, a selective COX-2 inhibitor.
URI
http://dspace.inha.ac.kr/handle/10505/1570
ISSN
0017-5749
Appears in Collections:
Medical School/College of Medicine (의학전문대학원/의과대학) > Medical Science (의학) > Journal Papers, Reports(의학 논문, 보고서)
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